GREAT AT SMALL THINGS

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BCCM wishes you a Merry Christmas & Happy New Year 2019 !

 

 

  • The plasmid "pCAXL-NB5.D9 escape  (LMBP 9323)" carries the NB5 escape mutant D9 of the Influenza A virus NIBRG-14 (H5N1) neuraminidase cDNA. Influenza virus neuraminidase is an interesting target of small-molecule antiviral drugs. See Cardoso et al., J. Virol. 88 (2014), 8278-8296 [PMID: 24829341].
  • Mycobacterium tuberculosis subsp. complex (ITM-000611) is one of the 229 clinical M. tuberculosis isolates (single-colony derived cultures) of the TDR-TB Strain Bank. This is a high quality bioresource for basic science, supporting the development of new diagnostics and drug-resistance detection tools and providing reference materials for laboratory quality management programmes.  https://www.who.int/tdr/news/2013/tb-strain-bank/en/
  • Penicillium chrysogenum (IHEM 26402) is a source of several antibiotics, most significantly penicillin, the first antibiotic, discovered by Alexander Fleming in 1928. Penicillin works against gram-positive bacteria, such as Staphylococcus and Pneumococcus, by disrupting bacterial cell wall synthesis.
  • Diatoms such as Thalassiosira weissflogii (DCG 0320) are key organisms in the production of long chain polyunsaturated fatty acids (LC-PUFAs) in marine food webs. LC-PUFAs such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are considered essential omega-3 fatty acids in human nutrition.
  • Botrytis cinerea (MUCL 43838) is a microscopic fungus responsible for the magic of Sauternes. This species occurs in vineyards, where in some cultivars and under certain climatic conditions, in autumn, it consumes part of the sugar and acidity of the ripe grapes. This process, known as 'noble rot', results in distinctive sweet dessert wines, such as Sauternes.

  • Lactobacillus delbrueckii subsp. bulgaricus (LMG 6901) is the main bacteria used for the production of yogurt. It is also found in other naturally fermented products. First identified in 1905 by the Bulgarian doctor Stamen Grigorov, the bacterium feeds on lactose to produce lactic acid, which is used to preserve milk.
  • Cyanobacteria, e.g. Wilmottia murrayi (ULC 034) have been very important for the evolution of our Planet. Their ability to perform oxygenic photosynthesis has been the key element of the Great Oxidation Event (GOE) that transformed the primitive Earth atmosphere from a reduced to an oxidized state about 2.3 billion years ago. With sufficient oxygen to breathe, evolution of the eukaryotes could proceed, and eventually, mankind could evolve.