The global burden of multi-drug tuberculosis (MDR-TB) was estimated in 2013 at 5.3% of TB cases, including 9% with extensively drug-resistant tuberculosis (XDR-TB)1. Only 48% of MDR cases were treated successfully, in part due to high toxicity, the long duration of the current regimens, and drug supply interruptions. To overcome these constraints, new TB drugs were deemed essential and have been developed, yet their safety and efficacy are being assessed in Phase II and III clinical trials for patients with MDR-TB.
New publication by Siva L.S. Velivelli, Paul De Vos, Peter Kromann,Stephane Declerck, Barbara D. Prestwich in Trends in Biotechnology
This article focuses on the problems and challenges encountered when introducing biological control agents on the market. The role that culture collections, such as the BCCM collections, can play in this process is described.
From the 29th of September until the 3th of October, training in Mycology is organised at BCCM/IHEM. This one week training is focusing on Fungi of the human environment and includes a theoretical part as well as practical training in the laboratory.
Interested in such a training? Need more details?
Please contact us at firstname.lastname@example.org
The hORFv8.1 database consists of a sequence-verified, clonal collection of human Open Reading Frames (ORFs), presented as Gateway Entry vectors (backbone: pDONR223). All clones come without a termination codon, allowing the addition of C-terminal tags or markers.
BCCM/LMBP provides this large collection as individual plasmids, and offers a range of compatible Gateway Destination vectors, aiming to satisfy your imagination for your experimental set-ups.
See the BCCM/LMBP ORFeome v8.1 entry plasmids catalogue here.
This collection from the Belgian Nuclear Research Centre (SCK.CEN) provides historical reference plasmids for various incompatibility families. The collection also includes a set of bacterial host strains meant for cloning and in vitro packaging of and/or working with phages.
Since many years, the BCCM consortium is actively involved in European and international associations of culture collections such as the European Culture Collections' Organisation (ECCO) and the World Federation of Culture Collections (WFCC).
Prof. Jody Haig's research group (IRC, VIB, Ghent, Belgium) developed a highly efficient Gateway- and recombinase-mediated cassette exchange (RMCE)-compatible system to target conditional and/or inducible constructs to the ROSA26 locus of F1 hybrid Bl6/129 ESCs, called G4 ROSALUC ES cells.
This technology allows researchers to easily create conditional and/or inducible ROSA26 alleles in a time/cost efficient manner.